Preheat oven to 375°F. Cook noodles until al dente. Spray and set aside.
Mash bread and milk. Mix in beef, salt, and pepper. Sauté onion, garlic, oregano, and red pepper. Brown beef mixture. Add tomatoes and simmer.
Whisk cream sauce ingredients together.
Layer noodles, meat sauce, cream sauce, and mozzarella in a 13×9 dish. Repeat layers, ending with noodles, cream sauce, mozzarella, and Pecorino.
Cover with greased foil. Bake 30 minutes. Uncover and bake 25 to 30 minutes until spotty brown.
Cool for 30 minutes before slicing.